How and where to order Cyclopentolate Hydrochloride (Cyclogyl) 1% 5 ml ophthalmic solution online on American Board of Clinical Optometry website:
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Cyclopentolate (trade names include Cyclogyl, Ciclolux, Ciclopentolato, Cicloplegico, Colircusi Cicloplejico, Cyclomed, Cyclopent, Cyclopentolat Alcon, Minims Cyclopentolate) is an ophthalmological mydriatic and cycloplegic medication from anticholinergics pharmacological group. This medicine is used during eye examinations that dilates the eye (mydriatic), prevents accommodation of the eye to different distances (cycloplegic). It is usually indicated for diagnostic procedures. Cyclopentolate (Cyclogyl) is also prescribed as an atropine substitute to reverse muscarinic and CNS effects of indirect cholinomimetic (anti-AChase) administration.
Bimatoprost (Careprost, Latisse, Lumigan)
Cyclopentolate, Phenylephrine (Cyclomydril)
Dorzelamidel, Timolol Maleate (Cosopt)
Epinephrine Hydrogen Tartrate, Pilocarpine Hydrochloride (Epilo)
Phenylephrine, Tropicamide (Mydrin-P)
Scopolamine (Isopto Hyoscine)
Pharmacological and medical categories:
Eye care medications
S - Sensory organs
S01 - Ophthalmologicals
S01F - Mydriatics and cycloplegics
S01FA - Anticholinergics
S01FA04 - Cyclopentolate
Disorders of ocular muscles, binocular movement, accommodation and refraction - H49-H52
Disorders of refraction and accommodation - H52
Encounter for other special examination without complaint, suspected or reported diagnosis - Z01
Encounter for examination of eyes and vision without abnormal findings - Z01.00
Indications and usage:
Cyclogyl (Cyclopentolate Hydrochloride) ophthalmic solution is used to produce mydriasis and cycloplegia.
Dosage and administration:
Instill one or two drops of 0.5%, 1% or 2% solution in the eye which may be repeated in five to ten minutes if necessary. Complete recovery usually occurs in 24 hours. Complete recovery from mydriasis in some individuals may require several days.
Instill one or two drops of 0.5%, 1% or 2% solution in the eye which may be repeated five to ten minutes later by a second application of 0.5% or 1% solution if necessary.
A single instillation of one drop of 0.5% in theeye. To minimize absorption, apply pressure over the nasolacrimal sac for two to three minutes. Observe infant closely for at least 30 minutes following instillation. Individuals with heavily pigmented irides may require higher strengths.
Dosage forms and strengths:
Cyclogyl (Cyclopentolate Hydrochloride) eye drops 0.5%, 1%, 2% in multiple-dose plastic dispensers 2 ml, 5 ml, 15 ml.
Excessive dosage may produce behavioral disturbances, tachycardia, hyperpyrexia, hypertension, elevated intraocular pressure, vasodilation, urinary retention, diminished gastrointestinal motility and decreased secretion in salivary and sweat glands, pharynx, bronchi and nasal passages. Patients exhibiting signs of overdosage should receive supportive care and monitoring.
Ophthalmic Cyclopentolate HCl should not be used when untreated narrow-angle glaucoma, or untreated anatomically narrow angles are present, or if the patient is hypersensitive to any component of this medication.
Cyclogyl (Cyclopentolate HCl) eye drops is for topical ophthalmic use only, not for injection. This medication may cause CNS disturbances. This is especially true in younger age groups, but may occur at any age, especially with the stronger solutions. Infants are especially prone to CNS and cardiopulmonary side effects from cyclopentolate. To minimize absorption, use only 1 drop of 0.5% Cyclogyl solution per eye, followed by pressure applied over the nasolacrimal sac for two to three minutes. Observe infants closely for at least 30 minutes following instillation.
Mydriatics may produce a transient elevation of intraocular pressure.
The lacrimal sac should be compressed by digital pressure for two to three minutes after instillation to reduce excessive systemic absorption. Caution should be observed when considering use of this medication in the presence of Down's syndrome and in those predisposed to angle-closure glaucoma.
Side effects, adverse reactions:
Most common adverse reactions of Cyclogyl eye drops are increased intraocular pressure, burning, photophobia, blurred vision, irritation, hyperemia, conjunctivitis, blepharoconjunctivitis, punctate keratitis, synechiae.
Use of cyclopentolate has been associated with psychotic reactions and behavioral disturbances, usually in children, especially with 2% concentration. These disturbances include ataxia, incoherent speech, restlessness, hallucinations, hyperactivity, seizures, disorientation as to time and place, and failure to recognize people. This drug produces reactions similar to those of other anticholinergic drugs, but the central nervous system manifestations as noted above are more common. Other toxic manifestations of anticholinergic drugs are skin rash, abdominal distention in infants, unusual drowsiness, tachycardia, hyperpyrexia, vasodilation, urinary retention, diminished gastrointestinal motility and decreased secretion in salivary and sweat glands, pharynx, bronchi and nasal passages. Severe manifestations of toxicity include coma, medullary paralysis and death.
Cyclopentolate (Cyclogyl) may interfere with the ocular anti-hypertensive action of carbachol, pilocarpine, or ophthalmic cholinesterase inhibitors.
Use in specific populations:
Animal reproduction studies have not been conducted with cyclopentolate. It is also not known whether cyclopentolate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Cyclogyl should be administered to a pregnant woman only if clearly needed.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when cyclopentolate hydrochloride is administered to a nursing woman.
Use of Cyclogyl has been associated with psychotic reactions and behavioral disturbances in pediatric patients. Increased susceptibility to cyclopentolate has been reported in infants, young children, and in children with spastic paralysis or brain damage. These disturbances include ataxia, incoherent speech, restlessness, hallucinations, hyperactivity, seizures, disorientation as to time and place, and failure to recognize people. Feeding intolerance may follow ophthalmic use of this product in infants. It is recommended that feeding be withheld for four hours after examination. Observe infants closely for at least 30 minutes.
No overall differences in safety or effectiveness have been observed between elderly and younger patients.
Information for patients:
Do not touch dropper tip to any surface, as this may contaminate the solution.
A transient burning sensation may occur upon instillation.
Patients should be advised not to drive or engage in other hazardous activities while pupils are dilated.
Patients may experience sensitivity to light and should protect eyes in bright illumination during dilation.
Parents should be warned not to get this preparation in their child's mouth and to wash their own hands and the child's hands following administration.
Feeding intolerance may follow ophthalmic use of this product in infants. It is recommended that feeding be withheld for four hours after examination.
C - Australia
C - United States (Risk cannot be ruled out)
Salts and other forms:
Synonyms, international and chemical names:
Cloridrato de Ciclopentolato
Brands, generics, trade names:
AK-Pentolate - Akorn
Ciclolux - Allergan
Ciclopegic - Llorens
Ciclopenal - Alcon
Ciclopentolato - Oftalmoquimica
Cicloplegico - Allergan
Cicloplejico - Alcon
Colircusi Cicloplejico - Alcon
Cyclogyl - Alcon, Intas Pharmaceuticals, Novartis
Cyclomed - Promed Exports
Cyclomydri - Alcon
Cyclopent - Sun Pharmaceutical Industries
Cyclopentolat - Alcon
Cyclopentolate - Akorn, Alcon
Cylate - CYNACON / OCuSOFT
Minims Cyclopentolate - Chauvin Pharmaceuticals, Apex Pharma, Bausch and Lomb, U.S. Summit, Valeant Pharmaceuticals
Mydrilate - Intrapharm Laboratories, United Drug
Pentolate - Sunways India
Skiacol - Alcon
Zyklolat-EDO - Dr. Gerhard Mann
APIs used in medicine in combinations with cyclopentolate:
Here is a list of popular medications containing cyclopentolate as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
|Trade name of the drug
||Pharmaceutical forms and doses
||Drops; Ophthalmic; Cyclopentolate Hydrochloride 1%
||Solution; Ophthalmic; Cyclopentolate Hydrochloride 0.5%Solution; Ophthalmic; Cyclopentolate Hydrochloride 1%Solution; Ophthalmic; Cyclopentolate Hydrochloride 2%
||AlconAndre LaboratoriesDKSHFirma Chun CheongIntas PharmaceuticalsNovartisSummit
||Drops; Ophthalmic; Cyclopentolate Hydrochloride 1%
||Sun Pharmaceutical IndustriesMilmet Pharma
||Solution; Ophthalmic; Cyclopentolate Hydrochloride 0.5%Solution; Ophthalmic; Cyclopentolate Hydrochloride 1%
||Chauvin PharmaceuticalsApex PharmaBausch and LombPan-Malayan PharmaceuticalsRich Plan InternationalU.S. SummitValeant PharmaceuticalsZuellig Pharma
Cyclopentolate main article on Wikipedia: https://en.wikipedia.org/wiki/Cyclopentolate
Cyclopentolate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Cyclopentolate
Cyclopentolate Hydrochloride compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Cyclopentolate-hydrochloride
Cyclopentolate medicine on DrugBank: https://go.drugbank.com/drugs/DB00979
Cyclopentolate Hydrochloride on DrugBank: https://go.drugbank.com/salts/DBSALT000476
Cyclopentolate Ophthalmic FAQ on MedlinePlus (revised 03/15/2016): https://medlineplus.gov/druginfo/meds/a616014.html
Cyclopentolate Hydrochloride solution/drops drug label on DailyMed (revised October 8, 2020): https://dailymed.nlm.nih.gov/dailymed/lookup...
Cyclogyl (Cyclopentolate Hydrochloride) solution/drops drug label on DailyMed (revised December 21, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Cyclopentolate containing drugs on Drugs-About.com: https://drugs-about.com/ing/cyclopentolate.html
Cyclopentolate for sale on Pharma Doctor: https://pharma-doctor.com/cyclopentolate.html
Cyclogyl (Cyclopentolate Hydrochloride ophthalmic solution, USP) official prescribing information from Alcon pharmaceutical company (revised October 2015): http://embed.widencdn.net/pdf/plus/alcon/...
Cyclogyl (Cyclopentolate Hydrochloride) ophthalmic solution full prescribing information on Drugs.com (revised December 1, 2020): https://www.drugs.com/pro/cyclogyl.html
Cyclogyl (Cyclopentolate Hydrochloride) eye drops 1% consumer medicine information on NPS MedicineWise (revised October 2020): https://www.nps.org.au/assets/medicines/...
Minims Cyclopentolate Hydrochloride 0.5% and 1% eye drops patient information leaflet from Medicines.org.uk (revised March 2020): https://www.medicines.org.uk/emc/files/pil.3741.pdf
Revised: April 2021
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